Staphylococcus aureus, a common cause of serious and often fatal infections, is well-armed with secreted factors that disarm host immune defenses.Highly expressed in vivo during infection, Staphylococcal protein A (SpA) is reported to also contribute to nasal colonization that can be a prelude to invasive infection.Co-evolution with the host immune
The study of biological processes has become increasingly reliant on obtaining high-resolution spatial and temporal data through imaging techniques.As researchers demand molecular resolution of cellular events in the context of whole organisms, correlation of non-invasive live-organism imaging with electron microscopy in complex three-dimensional s
The efficiency of a locomotive fleet as a complex system depends significantly on the mode and conditions of its operation, which, in many cases, are determined both by its own condition and by the state of the maintenance system.In reality, changes in the state of the system, and its further behaviour in most cases can be described by the Markov p
Abstract Background Integrons are mechanisms that facilitate horizontal gene transfer, allowing bacteria to integrate and express foreign DNA.These are important in the exchange of antibiotic resistance determinants, but can also transfer a diverse suite of genes unrelated to pathogenicity.Here, we provide a systematic analysis of the distribution
New scholarship has identified trends, constraints, and opportunities for climate litigation in the Global South.While countries in the Global South tend to experience a lack of capacity within government agencies, PRENATAL civil society, and the judiciary, the Global South is not a homogenous group.Where climate litigation has been identified, the